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Norfloxacin should be given with extreme care to patients with a history of seizures, severe cerebrovascular disease and severe renal damage. Anaphylactic reactions have been reported with quinolones. Patients should be instructed to take adequate amount of water. Exposure to sunlight should be avoided.
Use in pregnancy & lactation: There is no evidence that norfloxacin has any teratogenic effect. Restraint in the use of norfloxacin during pregnancy is recommended as a matter of principle, rather than because of demonstrated fetotoxicity. Tinidazole readily crosses the placenta and is distributed into breast milk. Tinidazole should not be given during the 1st trimester of pregnancy and is not recommended in lactation.
Use in children: The fluoroquinolones should preferably not be used in children and adolescents.
